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Do guidelines influence emergency department staff behaviours and improve patient outcomes? Evaluation of a multi-faceted intervention for the implementation of local Acute Exacerbation of Chronic Obstructive Pulmonary Disease guidelines
What is the optimal management of potentially resectable stage III-N2 NSCLC? Results of a fixed-effects network meta-analysis and economic modelling.
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H Daly, Nicky J Welton, Shahzeena Aslam, Doug West, Neal Navani
Apr 17, 2023
INTRODUCTION: There is a critical need to understand the optimal treatment regimen in patients with potentially resectable stage III-N2 nonsmall cell lung cancer (NSCLC). METHODS: A systematic review of randomised controlled...
Label-free cell segmentation of diverse lymphoid tissues in 2D and 3D.
John W Wills, Jack Robertson, Pani Tourlomousis, Clare M C Gillis, Claire M Barnes, Michelle Miniter, Rachel E Hewitt, Clare E Bryant, Huw D Summers, Jonathan J Powell, Paul Rees
Apr 17, 2023
Unlocking and quantifying fundamental biological processes through tissue microscopy requires accurate, in situ segmentation of all cells imaged. Currently, achieving this is complex and requires exogenous fluorescent...
confocal microscopy immunofluorescence Tissue Quantitative Cell segmentation 3D digital pathology Label Free 2D single-cell
Published by: Cell reports methods
Review of Susan Dodd and Neil Robertson, eds., Hegel and Canada. Unity of Opposites? University of Toronto Press, 2018. 408 pages
James Scott Johnston
Jan 07, 2019
As is the case with most western, liberal-democratic nations, Canada’s metanarratives are far from simple. Indeed, the overarching stories Canadians tell themselves are frequently qualified by the insistence (often from...
Published by: Memorial University of Newfoundland
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Edward Jenkins, Markus Körbel, Caitlin O'Brien-Ball, James McColl, Kevin Y Chen, Mateusz Kotowski, Jane Humphrey, Anna H Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F Lee, Simon J Davis, David Klenerman
Apr 17, 2023
T cells use finger-like protrusions called 'microvilli' to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a...
T-Lymphocytes microvilli Receptors Antigen T-Cell Antigens Lymphocyte Activation Signal Transduction
Published by: Nature Communications
The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland
David J. Pascall, Elen Vink, Rachel Blacow, Naomi Bulteel, Alasdair Campbell, Robyn Campbell, Sarah Clifford, Chris Davis, Ana da Silva Filipe, Noha El Sakka, Ludmila Fjodorova, Ruth Forrest, Emily Goldstein, Rory Gunson, John Haughney, Matthew T. G. Holden, Patrick Honour, Joseph Hughes, Edward James, Tim Lewis, Samantha Lycett, Oscar MacLean, Martin McHugh, Guy Mollett, Yusuke Onishi, Ben Parcell, Surajit Ray, David L. Robertson, Sharif Shabaan, James G. Shepherd, Katherine Smollett, Kate Templeton, Elizabeth Wastnedge, Craig Wilkie, Thomas Williams, Emma C. Thomson, The COVID-19 Genomics UK (COG-UK) Consortium
Apr 13, 2023
RESEARCH ARTICLE People and places Physical sciences Biology and life sciences Medicine and Health Sciences Computer and information sciences
Published by: Public Library of Science
CEERS Key Paper. III. The Diversity of Galaxy Structure and Morphology at z = 3–9 with JWST
Jeyhan S. Kartaltepe, Caitlin Rose, Brittany N. Vanderhoof, Elizabeth J. McGrath, Luca Costantin, Isabella G. Cox, L. Y. Aaron Yung, Dale D. Kocevski, Stijn Wuyts, Henry C. Ferguson, Micaela B. Bagley, Steven L. Finkelstein, Ricardo O. Amorín, Brett H. Andrews, Pablo Arrabal Haro, Bren E. Backhaus, Peter Behroozi, Laura Bisigello, Antonello Calabrò, Caitlin M. Casey, Rosemary T. Coogan, M. C. Cooper, Darren Croton, Alexander de la Vega, Mark Dickinson, Adriano Fontana, Maximilien Franco, Andrea Grazian, Norman A. Grogin, Nimish P. Hathi, Benne W. Holwerda, Marc Huertas-Company, Kartheik G. Iyer, Shardha Jogee, Intae Jung, Lisa J. Kewley, Allison Kirkpatrick, Anton M. Koekemoer, James Liu, Jennifer M. Lotz, Ray A. Lucas, Jeffrey A. Newman, Camilla Pacifici, Viraj Pandya, Casey Papovich, Laura Pentericci, Pablo G. Pérez-González, Jayse Petersen, Nor Pirzkal, Marc Rafelski, Swara Ravindranath, Raymond C. Simons, Gregory F. Snyder, Rachel S. Somerville, Elizabeth R. Stanway, Amber N. Straughn, Sandro Tacchella, Jonathan R. Trump, Jesús Vega-Ferrero, Stephen M. Wilkins, Guang Yang, Jorge A. Zavala
Apr 14, 2023
We present a comprehensive analysis of the evolution of the morphological and structural properties of a large sample of galaxies at z = 3–9 using early James Webb Space Telescope (JWST) CEERS NIRCam observations. Our sample...
Published by: The American Astronomical Society
CEERS Key Paper. II. A First Look at the Resolved Host Properties of AGN at 3 < z < 5 with JWST
Dale D. Kocevski, Guillermo Barro, Elizabeth J. McGrath, Steven L. Finkelstein, Micaela B. Bagley, Henry C. Ferguson, Shardha Jogee, Guang Yang, Mark Dickinson, Nimish P. Hathi, Bren E. Backhaus, Eric F. Bell, Laura Bisigello, Véronique Buat, Denis Burgarella, Caitlin M. Casey, Nikko J. Cleri, M. C. Cooper, Luca Costantin, Darren Croton, Emanuele Daddi, Adriano Fontana, Seiji Fujimoto, Jonathan P. Gardner, Eric Gawiser, Mauro Giavalisco, Andrea Grazian, Norman A. Grogin, Yuchen Guo, Pablo Arrabal Haro, Michaela Hirschmann, Benne W. Holwerda, Marc Huertas-Company, Taylor A. Hutchison, Kartheik G. Iyer, Brenda Jones, Stéphanie Juneau, Jeyhan S. Kartaltepe, Lisa J. Kewley, Allison Kirkpatrick, Anton M. Koekemoer, Peter Kurczynski, Aurélien Le Bail, Arianna S. Long, Jennifer M. Lotz, Ray A. Lucas, Casey Papovich, Laura Pentericci, Pablo G. Pérez-González, Nor Pirzkal, Marc Rafelski, Swara Ravindranath, Rachel S. Somerville, Amber N. Straughn, Sandro Tacchella, Jonathan R. Trump, Stephen M. Wilkins, Stijn Wuyts, L. Y. Aaron Yung, Jorge A. Zavala
Apr 14, 2023
We report on the host properties of five X-ray-luminous active galactic nuclei (AGN) identified at 3 < z < 5 in the first epoch of imaging from the Cosmic Evolution Early Release Science Survey. Each galaxy has been imaged with...
Published by: The American Astronomical Society